Search all Publications of Villunger A.
   
Selected recent publications
     
  2017
     
  Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ.
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155.
PMID: 28085151
  Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156.
PMID: 28085150
  Haschka MD, Villunger A.
There is something about BOK we just don't get yet.
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.
PMID: 28262002
  Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt M, Kovarik P.
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection.
J Clin Invest. 2017 May 15. pii: 80631. doi: 10.1172/JCI80631. [Epub ahead of print]
PMID: 28504646
  Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A.
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene. 2017 Apr;36(15):2066-2073. doi: 10.1038/onc.2016.362.
PMID: 27694901
  Voráčová K, Hájek J, Mareš J, Urajová P, Kuzma M, Cheel J, Villunger A, Kapuscik A, Bally M, Novák P, Kabeláč M, Krumschnabel G, Lukeš M, Voloshko L, Kopecký J, Hrouzek P.
The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells.
PLoS One. 2017 Mar 2;12(3):e0172850. doi: 10.1371
PMID: 28253280
  Fava LL, Schuler F, Sladky V, Haschka MD, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg EA, Villunger A.
The PIDDosome activates p53 in response to supernumerary centrosomes.
Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.
PMID: 28130345
  2016
     
  Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.
Cell Death Differ. 2017 Jan 13. doi: 10.1038/cdd.2016.156. [Epub ahead of print]
PMID: 28085150
 
   
  Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ. 2016 Jan;23(1):41-51. doi: 10.1038/cdd.2015.61.
PMID: 26045049
 
   
  Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S.
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ. 2016 Feb;23(2):242-52. doi: 10.1038/cdd.2015.87.
PMID: 26138442
 
   
  Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M.
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011.
PMID: 27641098
 
   
  Tuzlak S, Kaufmann T, Villunger A.
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.
Genes Dev. 2016 Oct 1;30(19):2133-2151. Review.
PMID: 27798841
 
   
  Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A.
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene. 2016 Oct 3. doi: 10.1038/onc.2016.362. [Epub ahead of print]
PMID: 27694901
 
   
  Derudder E, Herzog S, Labi V, Yasuda T, Köchert K, Janz M, Villunger A, Schmidt-Supprian M, Rajewsky K.
Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells.
Proc Natl Acad Sci U S A. 2016 May 3;113(18):5065-70. doi: 10.1073/pnas.1604529113.
PMID: 27099294
   
  García Sáez AJ, Villunger A.
MOMP in the absence of BH3-only proteins.
Genes Dev. 2016 Apr 15;30(8):878-80. doi: 10.1101/gad.281519.116. Review.
PMID: 27083995
   
  Sakamoto K, Wehde BL, Yoo KH, Kim T, Rajbhandari N, Shin HY, Triplett AA, Rädler PD, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner KU.
Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.
Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. Print 2016 Jun 1.
PMID: 27044867
   
  Bauer E, Schlederer M, Scheicher R, Horvath J, Aigner P, Schiefer AI, Kain R, Regele H, Hoermann G, Steiner G, Kenner L, Sexl V, Villunger A, Moriggl R, Stoiber D.
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.
Oncotarget. 2016 Mar 15;7(11):12191-205. doi: 10.18632/oncotarget.7687.
PMID: 26919255
   
  Podmirseg SR, Jäkel H, Ranches GD, Kullmann MK, Sohm B, Villunger A, Lindner H, Hengst L.
Caspases uncouple p27Kip1 from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion.
Oncogene. 2016 Feb 1. doi: 10.1038/onc.2015.524.
PMID: 26829051
   
  Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A.
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. Epub 2015 Oct 9.
PMID: 26450454
   
  2015
   
  Woess C, Drach M, Villunger A, Tappert R, Stalder R, Pallua JD.
Application of mid-infrared (MIR) microscopy imaging for discrimination between follicular hyperplasia and follicular lymphoma in transgenic mice.
Analyst. 2015 Sep 21;140(18):6363-72. doi: 10.1039/c5an01072a.
PMID: 26236782
  Fava LL, Rainer J, Haschka MD, Geley S, Villunger A.
Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly.
EMBO Rep. 2015 Oct;16(10):1233-6. doi: 10.15252/embr.201540731.
PMID: 26297610
   
  Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035.
PMID: 26387951
   
  Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A.
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ. 2015 Oct 9. doi: 10.1038/cdd.2015.130.
PMID: 26450454
  Knackmuss U, Lindner SE, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S.
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ. 2015 Jul 3. doi: 10.1038/cdd.2015.87.
PMID: 26138442
   
  Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A.
The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death.
Sci Rep. 2015 Jun 11;5:11268. doi: 10.1038/srep11268.
PMID: 26062895
   
  Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A.
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ. 2015 Jun 5. doi: 10.1038/cdd.2015.61.
PMID: 26045049
   
  Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N.
Expression of the vault RNA protects cells from undergoing apoptosis.
NatCommun. 2015 May 8;6:7030. doi: 10.1038/ncomms8030.
PMID: 25952297
   
  Haschka MD, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava LL.
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.
NatCommun. 2015 Apr 29;6:6891. doi: 10.1038/ncomms7891.
PMID: 25922916
   
  Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C.
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Cell Death Differ. 2015 Apr 10. doi: 10.1038/cdd.2015.31.
PMID: 25857265
   
  Woess C, Tuzlak S, Labi V, Drach M, Bertele D, Schneider P, Villunger A.
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Cell Death Differ. 2015 Feb 20. doi: 10.1038/cdd.2015.8.
PMID: 25698446
   
 

Piatti P, Lim CY, Nat R, Villunger A, Geley S, Shue YT, Soratroi C, Moser M, Lusser A.
Embryonic stem cell differentiation requires full length Chd1.
Sci Rep. 2015 Jan 26;5:8007. doi: 10.1038/srep08007.
PMID: 25620209

   
  Ottina E, Sochalska M, Sgonc R, Villunger A.
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell Death Dis. 2015 Jan 22;6:e1611. doi: 10.1038/cddis.2014.575.
PMID: 25611386
   
  Sochalska M, Tuzlak S, Egle A, Villunger A.
Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
FEBS J. 2015 Mar;282(5):834-49. doi: 10.1111/febs.13188. Epub 2015 Jan 23. Review.
PMID:25559680
   
  Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson GP.
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
J Immunol. 2015 Feb 1;194(3):1316-22. doi: 10.4049/jimmunol.1400637. Epub 2014 Dec 29.
PMID: 25548219
   
  Farrés J, Llacuna L, Martin-Caballero J, Martínez C, Lozano JJ, Ampurdanés C, López-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yélamos J.
PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.
Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.
PMID: 25501596
   
  2014
   
  Fava LL, Villunger A.
Stop competing, start talking!
EMBO J. 2014 Sep 1;33(17):1849-51. doi: 10.15252/embj.201489466. Epub 2014 Jul 25. Noabstractavailable.
PMID: 25063676
   
 

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L,
Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H77, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Cell Death Differ. 2014 Sep 19. Doi10.1038/cdd.2014.137
PMID:25236395.

   
 

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner- Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.
BIDdependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.
EMBO J. 2014 Jul 23. pii: e201387244. PMID:25056906.

   
 

Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A.
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.
Blood. 2014 Apr 24;123(17):2652-62. PMID:24632712.

   
 

Schweingruber N, Fischer HJ, Fischer L, van den Brandt J, Karabinskaya A, Labi V, Villunger A, Kretzschmar B, Huppke P, Simons M, Tuckermann JP, Flügel A, Lühder F, Reichardt HM.
Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses.
Acta Neuropathol. 2014 May;127(5):713-29. PMID:24488308.

   
  Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W.
Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1. J Leukoc
Biol. 2014 Jun;95(6):853-66 PMID: PMID:24295829.
   
  2013
   
  Baumgartner F, Woess C, Pedit V, Tzankov A, Labi V, Villunger A.
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene. 2013 Jan 31;32(5):621-30 PMID: 22430207.
   
 

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A.
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Cell Death Dis. 2013 Dec 5;4:e942 PMID: 24309929.

   
 

Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W.
Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol. 2013 Dec 2 PMID: 24295829.

   
 

Lindner SE, Wissler M, Gründer A, Aumann K, Ottina E, Peintner L, Brauns-Schubert P, Preiss F, Herzog S, Borner C, Charvet C, Villunger A, Pahl HL, Maurer U.
Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.
Oncogene. 2013 Nov 11 PMID: 24213575.

   
  Fava LL, Haschka MD, Villunger A.
Bim vanishes in the light of a mitotic Aurora.
Cell Death Differ. 2013 Dec;20(12):1597-8 PMID: 24212928.
   
  Wensveen FM, Geest CR, Libregts SF, Derks IA, Ekert PG, Labi V, Villunger A, Nolte MA,
Eldering E. BH3- only protein Noxa contributes to apoptotic control of stress-erythropoiesis.
Apoptosis. 2013 Nov;18(11):1306-18 PMID: 23975731.
   
  Hannesdóttir L, Tymoszuk P, Parajuli N, Wasmer MH, Philipp S, Daschil N, Datta S, Koller JB, Tripp CH, Stoitzner P, Müller-Holzner E, Wiegers GJ, Sexl V, Villunger A, Doppler W.
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response.
Eur J Immunol. 2013 Oct;43(10):2718-29 PMID: 23843024.
   
  Ottina E, Pellegrini M, Villunger A.
Guarding effector T-cell survival: all for one, Mcl-1 for all?
Cell Death Differ. 2013 Aug;20(8):969-71 PMID: 23832147.
   
  Egle A, Asslaber D, Villunger A, Pinon-Hofbauer J.
Bid-ding for mercy: twisted killer in action.
Cell Death Differ. 2013 Jul;20(7):847-9 PMID: 23749178.
   
  Farrés J, Martín-Caballero J, Martínez C, Lozano JJ, Llacuna L, Ampurdanés C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yélamos J.
Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.
Blood. 2013 Jul 4;122(1):44-54 PMID: 23678004.
   
  González-Gironès DM, Moncunill-Massaguer C, Iglesias-Serret D, Cosialls AM, Pérez-Perarnau A, Palmeri CM, Rubio-Patiño C, Villunger A, Pons G, Gil J.
AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts.
Apoptosis. 2013 Aug;18(8):1008-16 PMID: 23605481.
   
  Manzl C, Baumgartner F, Peintner L, Schuler F, Villunger A.
Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines.
Methods. 2013 Jun 1;61(2):130-7 PMID: 23454286.
   
  Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A.
Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ. 2013 Apr;20(4):546-57 PMID: 23238565.
   
  Labi V, Bertele D, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger A, Erlacher M.
Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3- only proteins Bim and Bmf.
EMBO Mol Med. 2013 Jan;5(1):122-36 PMID: 23180554.