The laboratory's work focuses on the development of the immune system with an emphasis on cell death signalling, its cross talk to the cell cycle machinery, steroid hormones in the establishment of self-tolerance and miRNA function.

To uncover how malfunctions of the cell division cycle lead to the activation of the apoptotic machinery we combine live cell imaging with genetic approaches.
See examples below:

HeLa Kyoto cells stably expressing EGFP-α-tubulin and H2B-mCherry, depicted in red and green, respectively. The cell line was kindly provided by Daniel Gerlich, IMBA, Vienna.
(Click to open the movies)


Funding

FWF
AICR
EMBO
EU-FP6
Österreichische Krebshilfe

Ongoing projects: